Genomic instability and bystander effects induced by high-LET radiation
نویسندگان
چکیده
منابع مشابه
Bystander effects in radiation-induced genomic instability.
Exposure of GM10115 hamster-human hybrid cells to X-rays can result in the induction of chromosomal instability in the progeny of surviving cells. This instability manifests as the dynamic production of novel sub-populations of cells with unique cytogenetic rearrangements involving the "marker" human chromosome. We have used the comet assay to investigate whether there was an elevated level of ...
متن کاملRadiation-induced genomic instability and bystander effects: implications for radiation protection\*
Evidence has emerged over the past decade for the existence of two cellular phenomenons which challenge the standard paradigms for the induction of biological effects by ionizing radiation. In bnth cases, important genetic changes arke in cells that in themselves receive no radiation exposure. In the first, radiation induces a type of transmissible genomic instability in cells that leads to a p...
متن کاملBystander effects in UV-induced genomic instability: Antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation
BACKGROUND Genomic instability is characteristic of many types of human cancer. Recently, we reported that ultraviolet radiation induced elevated mutation rates and chromosomal instability for many cell generations after ultraviolet irradiation. The increased mutation rates of unstable cells may allow them to accumulate aberrations that subsequently lead to cancer. Ultraviolet A radiation, whic...
متن کاملGenomic Instability and Bystander Effect – Implications for Radiation Protection
The main results of the EC project ‘Genomic instability and radiation-induced cancer’ (RADINSTAB) are reviewed and the potential implications of genomic instability and bystander effect for risk assessment and radiation protection discussed. A basic paradigm in radiobiology is that, after exposure to ionising radiation, the deposition of energy in the cell nucleus and the resulting damage to DN...
متن کاملGenomic instability induced by ionizing radiation.
Genomic instability is characterized by the increased rate of acquisition of alterations in the mammalian genome. These changes encompass a diverse set of biological end points including karyotypic abnormalities, gene mutation and amplification, cellular transformation, clonal heterogeneity and delayed reproductive cell death. The loss of stability of the genome is becoming accepted as one of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2003
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1206900